By Guy F. Webster, Anthony V. Rawlings
Addressing probably the most as a rule encountered stipulations obvious by way of the dermatologist, this resource analyzes the pathophysiology, assessment, analysis, scientific good points, and keep an eye on of zits. With full-color illustrations, this resource delves into the on hand remedies for tough situations of zits and scarring and offers professional discussions of administration regimens together with topical and systemic cures, laser remedies, and new drugs.
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Additional info for Acne and its therapy
J Invest Dermatol 1983; 81:448–451. 115. Strauss JS, Kligman AM, Pochi PE. Effects of androgens and estrogens on human sebaceous glands. J Invest Dermatol 1962; 39:139– 155. 116. Sator PG, Schmidt JB, Sator MO, Huber JC, Honigsmann H. The influence of hormone replacement therapy on skin ageing: a pilot study. Maturitas 2001; 25:43 – 55. 117. Thornton MJ, Taylor AH, Mulligan K, et al. The distribution of estrogen receptor beta is distinct to that of the estrogen receptor a and the androgen receptor in human skin and the pilosebaceous unit.
Arch Biochem Biophys 1964; 105:634– 639. 78. Nicolaides N, Fu HC, Ansari MN, Rice GR. The fatty acids of wax esters and sterol esters from vernix caesosa and from human skin surface. Lipids 1972; 7:506 – 517. 79. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM. Identification of the D-6 desaturase of human sebaceous glands expression and enzyme activity. J Invest Dermatol 2003; 120:707–714. 80. Zheng Y, Eilertsen KJ, Ge L, et al. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse.
Both enzymes are inactivated by phosphorylation through a cAMP-activated protein kinase. Comparison of the kinetic parameters for these enzymes with those previously described in the literature found in other organs, indicates that the sebaceous gland enzymes have similar affinities for substrates and similar responses to allosteric effectors such as citrate. However, there are key points of differences and these will be discussed in turn. Squalene Biosynthesis Human sebum contains a high percentage of squalene, in contrast to the epidermal lipids, which contain a higher proportion of cholesterol.