By Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)
In hypersensitivity and Allergic illnesses: the recent Mechanisms and Therapeutics, a uncommon overseas panel of researchers and clinicians evaluation the newest findings at the mobile and molecular foundations of allergic ailments, really these of the airway, dermis, and bowel. the most important themes taken care of span the diversity from epidemiology and the mechanisms of irritation, to signaling in pathogenesis and allergies. every one contributor treats the pathophysiology of allergic reaction in quite a few organ-based ailments and syndromes, emphasizing very important new findings from mobile and molecular biology that remove darkness from those illnesses, but in addition display vital leads for the improvement of novel medications and healing suggestions.
hypersensitivity and Allergic illnesses: the recent Mechanisms and Therapeutics highlights the interface among easy and medical technology in allergic illness. Its up to date, clinically suitable procedure constitutes the hot regular wisdom base in medical immunology and hypersensitive reaction, not just for experts, but in addition for internists, for scientists learning the mobile and molecular biology of irritation and immunity, and for researchers excited about drug discovery and therapeutics. Authoritative and well timed, hypersensitivity and Allergic ailments is obviously the ultra-modern crucial new source for all physicians and investigators looking a deeper figuring out of allergic reaction in either its uncomplicated and scientific points.
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Extra info for Allergy and Allergic Diseases: The New Mechanisms and Therapeutics
J Exp Med 179: 1273-1283. 82. Yssel H, Fasler S, de Vries JE, de Waal Malefyt R (1994) IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T-cell clones. Int Immunol 6:1091-1096. 83. Parronchi P, De Carli M, Manetti R, Simonelli C, Sampognaro S, Piccinni MP, Macchia D, Maggi E, Del Prete G, Romagnani S (1992) IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Thl or Th2 human T-cell clones.
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A specific IL-13 binding protein (IL-13R a-chain) was recently identified by screening murine cDNA libraries for sequences homologous to members ofthe hemopoietin family (88). Stable expression of murine IL-13R a-chain in CTLL-2 cells resulted in generation of a highaffinity IL-13 binding complex, which was also capable of transducing a proliferative signal in response to IL-13 (88). Importantly, IL-4 and IL-13 were equally effective in competing for binding of 1251-labeled IL-13 to these cells, supporting the conclusion that both the common y-chain and the IL-13R a-chain can interact with the IL-4R a-chain to generate a high-affinity IL-4R complex.