By Carl Eisdorfer PhD MD
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Additional info for Annual Review of Gerontology and Geriatrics, Volume 4, 1984
Damage to the liver, for example, stimulates a regenerative burst in surviving hepatocytes. The connective tissue fibroblast will under normal steady-state conditions divide infrequently to replace losses by wear and tear. But following injury, they are capable of responding with cell proliferation to the extent that wound healing is complete. The tissue culture fibroblast is similar to its in vivo counterpart in that it divides following the "injury" of subculture until density-dependent inhibition occurs in confluent monolayers.
Cancer 46:1307, 1980. Muggia, F. Treatment medications which are age dependent. D. ), Perspectives on Prevention and Treatment of Cancer in the Elderly. , September, 1981. P. Cancer of the prostate. Clin. Oncol. 2:285, 1983. , et al. Epidemiology of cancer. A. ), Cancer, Principles and Practice of Oncology. Lippincott, Philadelphia, 1982. , and Pajak, T. Ten year results from the CALGB comparative study of a BCNU containing 4-drug program (BOPP) versus MOPP versus 3-day combinations in advanced Hodgkin's disease.
Those organs with most marked physiologic decline such as the lungs would be in most jeopardy. Also, side effects may be more hazardous, as in radiation therapy delivered to the oropharynx or oral cavity, because of the resultant loss of taste, dryness of the mucous membranes, and involution of the salivary glands. Combined with the precarious nutritional intake in the elderly, this can be lethal unless careful attention is given to nutritional support (Nixon and Lawson, 1983). Additionally, the usual treatment schedules often must be altered for the elderly due to their inability to tolerate daily treatment secondary to nausea, weakness, etc.