Download Antiandrogens in Prostate Cancer: A Key to Tailored by Louis Denis (auth.), Professor Dr. Louis Denis (eds.) PDF

By Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

The advent of maximal androgen blockade as a medical treatment by means of Brachi and Labrie greater than a decade in the past ended in a tremendous controversy at the scientific use of antiandrogens within the remedy of prostate melanoma. 3 consensus conferences have been in this case geared up with the aid of the yank melanoma Society, the Urological crew of the ecu association for study and remedy of melanoma and the foreign Prostate healthiness Council. the 1st result of the meta-analysis of twenty-two trials didn't placed an finish to the debate, even though, and clinicians have been left careworn via conflicting reviews released via dozens of specialists. The assembly in the back of the current quantity created a discussion board for the scientists who constructed the medicine and expert clinicians to supply a consensus. the result's an outline of the sector, condensed from countless numbers of courses. the knowledge has been up to date to supply special scientific symptoms for using antiandrogens together remedies and monotherapy for the person sufferer. we are hoping that this workforce attempt will facilitate ongoing discussions and bring about stronger sufferer care in addition to elevated wisdom of the medicine which are so very important to our sufferers' caliber of existence and survival.

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Extra resources for Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment

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6. ) Magnification: ca. x 250 Staining: Haematoxylin Eosin Surprisingly, the first established indication for CPA was suppression of drive in sexually deviant behaviour. CPA was introduced on the market in 1973 exclusively for this indication. Why were we surprised? Until the mid sixties it was firmly believed that the higher a particular species stood on the evolutionary ladder, the less the libido of the male individual was dependent on androgens. This means it should be possible to inhibit the libido of the male rat with an antiandrogen to a greater extent than that of the human male.

Springer Verlag, Berlin, Heidelberg, New York 1974 Vol XXXV12 pp 235-484 Neumann F: The anti androgen cyproterone acetate: Discovery, chemistry, basic pharmacology, clinical use and tool in basic research. Clin Exp Endocrinol 1994 (102 suppl):1-32 Neumann F, Steinbeck H and Hahn JD: Hormones and brain differentiation. In: Martini L, Motta M, Fraschini F (eds) The Hypothalamus. Academic Press, New York, London 1970 pp 569-603 Neumann F, Elger Wand Steinbeck H: Antiandrogens and reproductive development.

There are still no antiandrogenic preparations available for local use (topical application), although there is a certain need for them. Because of the effects of antiandrogens on, for example, spermatogene- sis, libido and potency, the systemic treatment of men with acne problems or baldness is not possible. The ideal solution would be a topically active antiandrogen without systemic sideeffects, but this problem has not yet been solved. Dorfman also mentioned hypertrichoSiS but, since androgens are not involved in the aetiology of this disorder, a therapeutic effect of antiandrogens is also unlikely.

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