Download Axonal Transport in Neuronal Growth and Regeneration by Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.) PDF

By Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.)

Over the previous numerous years, the velocity of analysis at the regulate of axonal progress has elevated at a awesome cost, and this job is mirrored in a growing to be literature facing a variety of points of axonal development and regener­ ation. apparently well timed to check the position performed through axonal delivery within the intrinsic responses of neurons within the development and regrowth approaches. in the course of the cooperation of the senior editors of this sequence, we've been given the chance to deliver this type of concentration to the present quantity. we want to recognize that the contributing authors attended a confer­ ence on "The function of Axonal delivery in Neuronal progress and Regenera­ tion" held in Tallahassee, Florida in March, 1983, subsidized through the Psycho­ biology examine heart of the Florida kingdom college. it's our wish that a few of the perceptions and insights expressed in those chapters resulted from our interactions.

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Extra resources for Axonal Transport in Neuronal Growth and Regeneration

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However, new insights into the basic properties of fast axonal transport are beginning to illuminate the roles that it may play during axonal growth. Although fast axonal transport is often used to refer solely to the movement of materials at the fastest orthograde rate, there is good reason for including in fast axonal transport the translocation of membranous organelles of all types in both directions (Lasek and Brady, 1982). The original descriptions of fast axonal transport (for example, see Lasek, 1967; Dahlstrom and Haggendahl, 1967; Grafstein, 1967) focused on the fastest moving elements leaving the cell bodies and defined this as fast axonal transport.

I I FIGURE 3. Various responses of the facial nerve cell bodies following different types of axonal injuries in different animal species. , 1982). Biochemical changes in the nerve cell body occur after the injection of botulinum toxin into the area of neuromuscular junction. Watson (1974) suggested that since botulinum toxin causes a block of synaptic vesicle release, endocytosis associated with recycling of membranes should also be inhibited, and, consequently, a block of uptake of a trophic substance from the periphery could cause the cell body changes.

J. Physiol. Pharmacol. 54:859-869. , 1980, Axonal growth during regeneration: A quantitative autoradiographic study, J. Cell Bioi. 87: 197-203. , 1976, Three-dimensional distribution of smooth endoplasmic reticulum in mylenated axons. J. Electron Micros, 25:141-149. , 1979, Morphological evidence for the involvement of the smooth endoplasmic reticulum in axonal transport, Brain Res. 174:315-318. , 1980, The movement of membranous organelles in axons: Electron microscopic identification of anterogradely and retrogradely transported organelles, J.

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