Download Bioactive Compounds from Marine Extremophiles by Lesley-Ann Giddings, David J. Newman PDF

By Lesley-Ann Giddings, David J. Newman

​This SpringerBrief sheds new mild on bioactive fabrics from marine extremophiles. It offers with all features of the chemicals produced through organisms residing lower than severe stipulations that could have capability as medicines or result in novel medicines for human use.

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Extra info for Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology / Extremophilic Bacteria)

Example text

2 μM, respectively. The potent cytotoxicity and selectivity of compounds 126–128 suggest that they may inhibit the growth of tumor cells by a specific, unknown mechanism of action. , isolated a family of novel 2-alkylidene-5-alkyl-4-oxazolidones, the lipoxazolidinones, from another species of Marinispora (NPS008920 strain) (Macherla et al. 2007). This actinomycete was isolated from sediments collected in Cocos Lagoon, Guam. Lipoxazolidinones A–C (130–132) (Fig. 8) were determined to be oxazolidinones with varying alkyl chain lengths.

Asolkar and coworkers reported the production of another family of bioactive cyclohexadepsipeptides produced by the S. arenicola strain CNT-088, which was isolated from a marine sediment collected from the Great Astrolab Reef in Kandavu Island chain, Fiji, at a depth of approximately 20 m (Asolkar et al. 2008). Arenamides A–C (166–168) (Fig. 9) are cyclic peptides composed of six amino acid residues with varying alkyl chain lengths. 7 cells, the production of proinflammatory mediators, iNOS, NO production as a result of iNOS, and prostaglandin E2 was determined.

Compound 125 is structurally similar to the oxazolomycins, which possess a spiro-β-lactone-γ-lactam bicyclic ring, an amide linkage joining C12 to C1, and the C1′ to C9′ carbon chain. The oxazolomycins have also been reported to have antiviral and antitumor activity (Ishihara and Hatakeyama 2014). Of all the oxazolomycins, total syntheses of only oxazolomycin A (Eto et al. 2011) and neooxazolomycin (Kende et al. 1990; Onyango et al. 2007) have been reported. However, the oxazolomycin biosynthetic gene cluster has been identified and may be useful in cloning the lajollamycin 125 gene cluster, which could be engineered to produce new metabolites (Zhao et al.

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