Download Breast Cancer and Molecular Medicine by Larry Norton, Clifford Hudis (auth.), Martine J. Piccart MD, PDF

By Larry Norton, Clifford Hudis (auth.), Martine J. Piccart MD, PhD, Mien-Chie Hung PhD, Lawrence J. Solin MD, Fatima Cardoso MD, William C. Wood MD (eds.)

Molecular-based drugs is taking heart level as a result of the expanding wisdom of breast melanoma molecular biology. remedy tailoring is not any longer a dream for the long run, however the major aim of present research.

This publication presents an summary of the newest ideas, brokers and methods for breast melanoma that give a contribution to the individualization of remedy. present biomedical learn makes a speciality of facilitating the move of molecular biology wisdom into the medical administration of sufferers, resulting in elevated survival in addition to better caliber of lifestyles. specific awareness is given during this ebook to organ-specific adapted methods, particular populations, sufferers’ personal tastes and rehabilitation. additionally mentioned extensive are the respective roles of pharmacotherapeutics modelling, practical imaging, molecular staging, genomics and proteomics and their impression at the "re-classification" of breast melanoma, in addition to the scientific purposes of uncomplicated technology. The an important factor of ways to optimally combine organic markers, new applied sciences and new diagnostic and healing methods into medical trials and medical perform is addressed.

Combining the contributions from authors who're popular specialists in those fields with editorial reviews, this booklet offers an outline of the most recent achievements in breast melanoma and their use in medical practice.

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Extra resources for Breast Cancer and Molecular Medicine

Example text

Benefits and Harms of Adjuvant Chemotherapy Preferences for Adjuvant Chemotherapy . . . . Benefits, Harms and Preferences for Adjuvant Endocrine Therapy . . . . . . . . . . . . . . Preferences for Adjuvant Radiation Therapy . . Preferences for Sentinel-Node Biopsy . . . . . Preferences for Breast Surgery . . . . . . . . Advanced Breast Cancer . . . . . . . . . . . Benefits and Harms of Palliative Chemotherapy Preferences for Palliative Chemotherapy .

Prognostic Factors . . . . . . . . . . . . . . Node Status . . . . . . . . . . . . . . . . . Tumor Size . . . . . . . . . . . . . . . . . Grade . . . . . . . . . . . . . . . . . . . . Hormone Receptors . . . . . . . . . . . . . Age . . . . . . . . . . . . . . . . . . . . . Pathology . . . . . . . . . . . . . . . . . . Treatment of Localized Disease . . . .

2 Introduction . . . . . . . . . . . . . . . . 977 Individual (Single) Prognostic and Predictive Markers . . . . . . . . . . . . . . . . . . . 980 ER/PR Status . . . . . . . . . . . . . . . . 980 HER2 . . . . . . . . . . . . . . . . . . . . 981 Urokinase-type Plasminogen Activator/ Plasminogen Activator Inhibitor Type I . . . . 983 Cyclin E . . . . . . . . . . . . . . . . . . . 984 Other Markers .

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