Download Breast Cancer Metastasis and Drug Resistance: Progress and by Jiemin Ma, Ahmedin Jemal (auth.), Aamir Ahmad (eds.) PDF

By Jiemin Ma, Ahmedin Jemal (auth.), Aamir Ahmad (eds.)

​This quantity comprehensively covers fresh prrogress in breast melanoma study. in order to effectively deal with breast melanoma, it's critical to a) absolutely comprehend the sickness with all its heterogeneity, b) comprehend the criteria that impression the metastasis of breast melanoma to far-off organs making it deadly and c) comprehend the underlying strategies that bring about the phenomenon of drug-resistance making the ailment really incurable. The ebook explores all of those matters, together with the phenomenon of epithelial-mesenchymal-transition, melanoma stem cells in addition to microRNAs in an try and greater comprehend the sickness in connection to its heterogeneity/metastasis/drug-resistance in addition to to suggest novel signaling pathways for healing intervention. The profiling of tumors to molecularly classify breast cancers can be investigated in order that custom-made specified cures could be constructed. ​

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The delayed response contributes to the higher mortality rate for AA patients. Moreover, due to the advanced stage, the cancer in the AA women is more likely to present with a larger tumor size and higher grade, which are well known factors that contribute to overall poor survival [1, 33]. Genetics also affects the susceptibility of patients to breast cancer and its treatments. Breast cancers would be typically treated with anti-estrogen therapy; however, AA patients, along with certain other minority groups, are more likely to have the estrogen receptor-negative (ER-) disease, which makes the therapy less effective [1].

Chlebowski RT, Hendrix SL, Langer RD et al (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s health initiative randomized trial. JAMA 289:3243–3253 22. Pelucchi C, Levi F, La Vecchia C (2010) The rise and fall in menopausal hormone therapy and breast cancer incidence. Breast 19:198–201 23. Breen N, Cronin KA, Tiro JA, Meissner HI, McNeel TS, Sabatino SA, Tangka FK, Taplin SH (2011) Was the drop in mammography rates in 2005 associated with the drop in hormone therapy use?

S. Coughlin and Y. Cypel 31. Lajous M, Boutron-Ruault MC, Fabre A, Clavel-Chapelon F, Romieu I (2008) Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am J Clin Nutr 87:1384–1391 32. Shikany JM, Redden DT, Neuhouser ML, Chlebowski RT, Rohan TE, Simon MS, Liu S, Lane DS, Tinker L (2011) Dietary glycemic load, glycemic index, and carbohydrates and risk of breast cancer in the women’s health initiative. Nutr Cancer 63:899–907 33.

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