By Marjorie Robert-Guroff, Robert C. Gallo (auth.), Ronald B. Herberman M.D. (eds.)
This quantity is the second one within the 'Cancer remedy and examine' sequence focussing on uncomplicated and scientific tumor immunology. It has a slightly assorted concentration or emphasis from that of the 1st quantity, released years in the past. That paintings (Basic and medical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) dedicated massive awareness to up dated summaries in numerous parts of classical tumor immunology: particular antitumor immunity, the immunologic competence of melanoma patietns, char acterization of human tumor-associated antigens, the facility to propagate particularly immune T cells in tradition within the presence of interleukin 2, and using such cells for adoptive immunotherapy of confirmed tumors. of facts in regards to the immune although, it additionally reviewed the prestige surveillance speculation and mentioned the necessity to contemplate non-T mobilephone mediated mechanisms of host resistance. specifically, one bankruptcy sum marized details at the position of macrophages in host resistance opposed to tumors. the current quantity maintains to stress one of many significant subject matters of the 1st quantity, cutting edge ways to the remedy of melanoma. It contains contributions from best investigators on a number of basic sorts of healing interventions on the topic of monoclonal antibodies, the col laboration of monoclonal antibodies with macro phages to mediate antibody established mobile cytotoxicity, lymphokines, tumor vaccines, and ordinary killer cells. It additionally has an up to date precis of the immunologic facets of the intriguing and promising paintings being played on human T cellphone leukemia virus within the laboratory of Dr. Robert Gallo.
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Extra info for Cancer Immunology: Innovative Approaches to Therapy
E. 1981. Immunological properties of a type C retrovirus isolated from cultured human T -lymphoma cells and comparison to other mammalian retroviruses. J. Viro!. 38:906-915. , Gallo, Re. 1983. Complete amino acid sequence of human T-cell leukemia virus structural protein p15. FEBS Letters 162:390-395. , Gallo, Re. 1984. Immunological characterization of the low molecular weight gag gene proteins p 19 and p 15 of human T-cell leukemia-lymphoma virus (HTLV) and demonstration of human natural antibodies to them.
Since publication of their work, a number of laboratories have essentially confirmed these observations using different tumors as well as newer, and presumably more sensitive, assay systems to detect evidence of specific tumor immunity [7, 8]. On the basis of these results, Hewitt has argued that there is an urgent need to use more appropriate and realistic animal tumor systems to study tumor immunology . And in a series of forcefully argued papers [10-12] he has advanced the disturbing notion that the demonstration of specific tumor immunity in animal systems is, for the most part, a consequence of a variety of laboratory artifacts.
Hinuma, Y. 1982. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Nat!. Acad. Sci. USA 79:2031-2035. 5. , Gallo, RC. 1983. Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 219:856-859. 6. , Metzgar, RS. 1983. Identification of human T -cell leukemia virus in a Japanese patient with adult T-cell leukemia and cutaneous lymphomatosis vasculitis. Proc. Nat!. Acad. Sci. USA 80: 2054-2058.