Download Cancer Immunotherapy: Paradigms, Practice and Promise by Tyler J. Curiel (auth.), Tyler J. Curiel (eds.) PDF

By Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)

This paintings will offer a historic viewpoint on tumor immunotherapy, talk about basic mechanisms of failed tumor rejection, examine passive recommendations to spice up anti-tumor immunity, in addition to have an in-depth examine lively innovations to spice up anti-tumor immunity.

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Zhang JP, Yan J, Xu J, Pang XH, Chen MS, Li L, Wu C et al (2009) Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 50:980–989 79. Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE et al (2007) Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med 204:1405–1416 80. Almeida JR, Price DA, Papagno L, Arkoub ZA, Sauce D, Bornstein E, Asher TE et al (2007) Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.

Abrogation of B7-H1 signaling enhanced myeloid DC-mediated T cell activation, which correlated with a decrease in T cellderived IL-10 and an increase in T cell-derived IL-2 and IFN-g. Interestingly, this treatment also downregulated IL-10 expression and stimulated increased IL-12 expression on myeloid DCs. T cells conditioned with myeloid DCs in which B7-H1 had been blocked could inhibit autologous human ovarian carcinoma growth better than unconditioned T cells when xenotransplanted into nonobese diabeticÀsevere combined immunodeficient mice.

Wilke et al. 49. Kusuda T, Shigemasa K, Arihiro K, Fujii T, Nagai N, Ohama K (2005) Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer. Oncol Rep 13:1153–1158 50. Ito N, Suzuki Y, Taniguchi Y, Ishiguro K, Nakamura H, Ohgi S (2005) Prognostic significance of T helper 1 and 2 and T cytotoxic 1 and 2 cells in patients with non-small cell lung cancer. Anticancer Res 25:2027–2031 51. Kondo T, Nakazawa H, Ito F, Hashimoto Y, Osaka Y, Futatsuyama K, Toma H et al (2006) Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1-type immune response.

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