By M. R. Berger (auth.), Prof. Dr. Dietrich Schmähl, Prof. Dr. Israel Penn (eds.)
In approximately five% of all organ (kidney, liver) transplant recipients, malignancies happen as a overdue hassle of the big immunosuppression. The malignancies are often dermis cancers, lymphomas and renal carcinomas. the current publication discusses the potential mechanisms of this kind of tumorigenesis and inquires into probabilities of prevention. particularly, the defined malignancies could be of viral beginning. The publication informs a few thoroughly new form of carcinogenesis. except the medical facets, it truly is of significant functional value.
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Additional info for Cancer in Organ Transplant Recipients
Hoeber-Harfer, New York, pp 529-532 Walder BK, Robertson MR, Jeremy D (1971) Skin cancer and immunosuppression. TOURAINE Severe lymphoproliferative disease (SLD) developed in 19 of the 1850 patients treated by kidney or kidney and pancreas transplantation in our institution. This type of malignancy could be reversed in some patients by early tapering of immunosuppressive therapy. Clinical Condition Three types of SLD were observed: - Type I. Eleven patients developed diffuse B-cell lymphoproliferation invading many organs.
1981, 1983). Three types of LPD have been identified: (a) benign polyclonal hyperplasias without cytogenetic abnormalities, (b) malig nant monoclonal lymphomas with clonal cytogenetic abnormalities, and (c) intermediate lesions that are morphologically malignant and contain clonal cytogenetic abnormalities in a subpopulation of cells, but are predominantly made up of a polyclonal B cell proliferation. W. Hanto (Hanto et aI1982). In a series of cardiac transplant recipients from Stanford, however, all the lymphoproliferative lesions were malignant morphologically and negative for surface and cytoplasmic immunoglobulin, thereby pre venting assessment of their clonality (Weintraub and Warnke 1982).
Discussion. Utilizing immunoglobulin gene rearrangement analyses in these two patients, we have confirmed that benign, polyclonal, B cell hyperplasias do occur in renal transplant recipients, as previously suspected (Hanto et al. 1981,1983,1985; Frizzera et al. 1981) Patients 1 and 2 had a clinical syndrome resembling infectious mononucleosis, serologic changes diagnostic of an acute reactivation or primary EBV infection, and EBV-DNA sequences within the biopsied tissue consistent with an acute EBV infection.