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J Cell Sci 90 ( Pt 3), 391-399. , et al. (2009). The selective hypoxia inducible factor1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther 8, 947-958. , and St Croix, B. (2007). Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 11, 539-554. L. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732. L. (2007a). Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 12, 853-859. L. (2007b).

Vane's discovery of the mechanism of action of aspirin changed our understanding of its clinical pharmacology. Pharmacol Rep 62, 518-525. , and Gilad, E. (2004). CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem 279, 26991-27007. A. (2008). Imaging of tumor glucose utilization with positron emission tomography. Cancer Metastasis Rev 27, 545-554. , and Denko, N. (2006). Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment.

F. (2007). The biology of cancer stem cells. Annu Rev Cell Dev Biol 23, 675-699. J. (2007). Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A 104, 32193224. , and Ruegg, C. (2008). The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 130, 1091-1103. , et al. (2005). The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump.

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