By Emil Frei III (auth.), K. Hellmann, T. A. Connors (eds.)
The foreign Society of Chemotherapy meets each years to check development in chemotherapy of infections and of malignant ailment. every one assembly will get higher to surround the extension of chemotherapy into new parts. In a few situations, enlargement has been fast, for instance in cephalosporins, pen icillins and mixture chemotherapy of melanoma - in others gradual, as within the box of parasitology. New difficulties of resistance and untoward results come up; aid of host toxicity with no lack of antitumour task via new elements occupies large realization. the enhanced effects with melanoma chemotherapy, es pecially in leukaemias, are resulting in a better occurrence of serious an infection in sufferers so taken care of, pharmacokinetics of substances in basic and diseased topics is receiving expanding realization in addition to comparable difficulties of bioavailability and interactions among medicinal drugs. in the meantime the assault on a few of the significant bacterial infections, similar to gonorrhoea and tubercu losis, that have been one of the first infections to think the effect of chemotherapy, nonetheless stay significant international difficulties and are actually lower than assault with new brokers and new tools. From this huge box and the 1,000 papers learn on the Congress now we have produced court cases which mirror the diversity and energy of study during this very important box of drugs. It was once impossible to incorporate the entire papers awarded on the Congress yet now we have tried to incorporate such a lot points of cur lease growth in chemotherapy.
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Extra info for Chemotherapy: Volume 7 Cancer Chemotherapy I
A thorough discussion of current directions in cancer chemotherapy is beyond the scope of this contribution. Instead, four specific areas under study in this Department are briefly described, as examples of the new approaches that are being pursued. The size of the metabolite pools in tumor cells can be expected to affect the activation of appropriate antimetabolites, their ability to compete successfully for specific enzyme sites, or the sensitivity of biochemical targets susceptible to feed-back control.
Rep. ~, 53 (1974). 31. J. -Forsch. ) ~, 1172 (1974). NEW LEADS TOWARDS ANTITUMOR SELECTIVITY IN THERAPEUTICS 1 Enrico Mihich Grace Cancer Drug Center, Roswell Park Memorial Institute N . Y. Y. 14263, USA SUMMARY Four approaches to cancer chemother apy currently being studied in this Department are discussed: 1) correlations between nucleotide pools in target tumor cells and selective activity of drugs; 2) reversal by a hormone of the host toxicity of an antitumor agent; 3) potential interference with cell division by uses of cyclic nucleotide analogs; and 4) increased antigenicity of leukemic lines resistant to certain drugs.
The use of suitable chemotherapeutic agents in inoperable and chemosensitive systemic tumour conditions is not only justified, but urgenly indicated for vital grounds. Even in juvenile patients drug treatment may be vitally indicated, as for instance in Burkitt's tumour, which can be cured in about 60% of the cases with high cyclophosphamide doses without any carcinogenic effect having been observed so far. The drugs should be selected for the individual conditions from a pharmacotherapeutic point of view, carefully pitting their therapeutic effectiveness in the respective type of tumour against the risks involved.