Download Clinical Uses of Botulinum Toxins by Anthony B. Ward, Michael P. Barnes PDF

By Anthony B. Ward, Michael P. Barnes

Botulinum pollution now play a really major position within the administration of a large choice of health conditions; from complications to hypersalivation, and from spasticity to sweating. during this ebook, a robust, overseas workforce of specialists define the fundamental neurochemistry of botulinum pollution and chart the development of the drug from laboratory to health facility. Then person chapters summarize their use for the most medical symptoms within the context of alternative on hand remedies. This publication might be of curiosity to neuroscientists and working towards clinicians operating in quite a lot of specialities, from neurology and dermatology to pediatrics, cosmetic surgery and rehabilitation medication.

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Extra resources for Clinical Uses of Botulinum Toxins

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PNAS, 101, 3208À13. 54. , Su¨dhof, T. C. and Niemann, H. (1994). Synaptic vesicle membrane fusion complex: action of Clostridial neurotoxins on assembly. , 13, 5051À61. 55. , Binz, T. and Davletov, B. (2004). A molecular basis underlying differences in the toxicity of botulinum serotypes A and E. , 5, 1090À5. 56. Dolly, J. O. (1997). Therapeutic and research exploitation of botulinum neurotoxins. Eur. J. , 4, S5À10. 26 J. O. Dolly and G. Lawrence 57. Smith, C. P. and Chancellor, M. B. (2004). Emerging role of botulinum toxin in the management of voiding dysfunction.

And Dolly, J. O. (1994). Botulinum A and the light chain of tetanus toxins inhibit distinct stages of MgATP-dependent catecholamine exocytosis from permeabilised chromaffin cells. Eur. J. , 222, 325À33. 39. Welch, M. , Purkiss, J. R. and Foster, K. A. (2000). Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins. Toxicon, 38, 245À58. 40. , Kemmer, T. P. and Gratzl, M. (1992). Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2þ, guanosine 5’-gamma-thio triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin.

2) acts as an efficient neuronal delivery vector for the light chain warhead. Removal of the light chain renders the remaining fragment non-toxic leaving a potential neuronal delivery vehicle for drugs/macromolecules. Neuronal binding fragments derived from the clostridial neurotoxins possess a number of properties that make them attractive candidates from which to develop a range of novel delivery vectors: they bind their receptors with high affinity (Kd < 10À9 M), they are specific for neuronal cells, and the targeted receptors are internalized into nerve endings.

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