By Sara Fuchs (auth.), W. Arber, S. Falkow, W. Henle, P. H. Hofschneider, J. H. Humphrey, J. Klein, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syruĉek, P. K. Vogt (eds.)
The examine of the genetic legislation of immune reaction to typical multidetermi nant immunogens used to be undertaken by means of the tactic of bidirectional selective breed ing of excessive or Low antibody responder strains of mice. 5 decisions are defined: choice I, performed for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in every one new release. choice II, performed for agglutinin responsiveness to sheep erythrocytes repeated in each one iteration. choice III and choice IV played respectively for agglutinin reaction to flagellar or somatic antigens of Salmonella typhimurium and Salmonella oranienburg alternated in every one new release. choice V, played for passive agglutinin reaction to bovine serum albumin and rabbit gamma globulin alternated in every one iteration. In every one choice the nature investigated is polygenic. low and high responder traces diverge gradually through the selective breeding. The maximal interline separation (selection restrict) is reached within the 7th-16th generations. low and high responder strains at choice restrict are thought of homozygous for the nature submitted to se~ection. Their variance is consequently basically as a result of environ psychological results. the adaptation in agglutinin titre among low and high traces is 220-fold in choice I, 103-fold in choice II, 90-fold in choice III, 85-fold in choice IV and 275-fold in choice V. The partition of genetic and environmental variances within the origin popu lations of the 5 decisions is confirmed. the percentage of genetic variance is 60% in choice I; forty nine% in choice II; fifty one% in choice III; forty seven% in choice IV and seventy six% in choice V.
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Extra resources for Current Topics in Microbiology and Immunology
Interline Crosses . . . . . . . . . . . C. Selection for Agglutinin Response to Salmonella Antigen . . . 1. Selection III for Agglutinin Response to f Antigen of Salmonella 2. Selection IV for Agglutinin Response to s Antigen of Salmonella . D. Selection V for Response to Bovine Serum Albumin (BSA) and Rabbit Gamma Globulin (RGG) . . . . . . . . . . . . . 1. Selective Breeding and Genetic Analysis. . . . . . . . 2. Kinetics of Primary and Secondary Antibody Responses to BSA and RGG E.
Sci. (in press) (1978b) Toyka, K. : Myasthenia gravis: Study of humoral immune mechanisms by passive transfer to mice. N. Eng!. J. Med. : Benefit from alternative day prednisone in myasthenia gravis. N. Eng!. J. Med. : Intrathymic pathogenesis and dual genetic control of myasthenia gravis. : Striated muscle fibers differentiate in monolayer cultures of adult thymus reticulum. : Rat skeletal muscle cells in Tissue Culture. In: Methods and Application. K. ) New York: Academic Press 1973, pp. , Fulpius, B.
K. ) New York: Academic Press 1973, pp. , Fulpius, B. : Study of two different subpopulations of antiacetylcholine receptor antibodies in a rabbit with experimental autoimmune myasthenia gravis. Eur. J. Immuno!. 8, 529-532 (1977) Genetics of Immunoresponsiveness to Natural Antigens in the Mouse G. Blozzli, D. A. C. PASSOS 3 , M. H. A. M. , Y. M. IBANEZ 2, C. STIFFEL 1, and M. SIQUEIRA 2 I. Introduction . . . . . . . . . II. Methods of Selective Breeding and Genetic Analysis . A. Selective Breeding.