Download DNA Damage and Repair: Volume III: Advances from Phage to by Jac A. Nickoloff, Merl F. Hoekstra PDF

By Jac A. Nickoloff, Merl F. Hoekstra

Jac A. Nickoloff and Merl F. Hoekstra replace and extend their previous acclaimed volumes (Vol. I: DNA fix in Prokaryotes and decrease Eukaryotes and Vol. II: DNA fix in larger Eurkaryotes) with state-of-the-art studies via prime gurus of basic experimental findings approximately DNA fix tactics in melanoma biology. The experiences disguise quite a lot of issues from viruses and prokaryotes to raised eukaryotes, and contain numerous new subject matters, between them the function of recombination in replication of broken DNA, X-ray crystallographic research of DNA fix protein buildings, DNA fix proteins and teleomere functionality, and the jobs of BRCA1 and BRCA2 in DNA fix. Authoritative and up to date, DNA harm and service, Vol. III: Advances from Phage to people surveys the speedily relocating study in DNA harm and service, and explains the real sensible relationships between diversified DNA fix pathways and the connection among DNA fix pathways, melanoma etiology, and melanoma treatments.

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Additional resources for DNA Damage and Repair: Volume III: Advances from Phage to Humans (Contemporary Cancer Research)

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E. Henderson. 1991. Enhanced pyrimidine dimer removal in repair-proficient murine fibroblasts transformed with the denV gene of bacteriophage T4. Mutat. Res. 255: 1–9. 47. , T. Mori, and D. H. Evans. 1996. Tobacco plants expressing T4 endonuclease V show enhanced sensitivity to ultraviolet light and DNA alkylating agents. Mutat. Res. 351: 19–31. 48. Masker, W. 1992. In vitro repair of double-strand breaks accompanied by recombination in bacteriophage T7 DNA. J. Bacteriol. 174: 155–160. 49. , and Wiberg, J.

Although a common thread between the latter three mutant strains is not apparent, all have a defect in DNA replication (and or cell viability) that is suppressed by some mutation (either rin-15 or lexA71::Tn5) and this new situation is then dependent on the recF gene product. It is not clear, however, if recF participates in a pathway that is active to a small degree in wild-type cells and this becomes the major pathway in the mutant cells, or if the pathway only becomes active in these “suppressed” states.

Charlesworth. 1998. Why sex and recombination? Science 281: 1986–1990. 3. , and A. Ghosh. 1987. Inducible reactivation of UV-irradiated cholera phage e5 in Vibrio cholerae. Mol. Gen. Genet. 209: 175–178. 4. Bernstein, C. 1981. Deoxyribonucleic acid repair in bacteriophage. Microbiol. Rev. 45: 72–98. 5. Bernstein, C. 1987. Damage in DNA of an infecting phage T4 shifts reproduction from asexual to sexual allowing rescue of its genes. Genet. Res. 49: 183–189. 6. , and S. S. Wallace. 1983. DNA repair, in Bacteriophage T4, (Mathews, C.

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