Download Gastrointestinal Cancer 1 by Eleanor E. Deschner, Remy J. Salmon (auth.), Jerome J. PDF

By Eleanor E. Deschner, Remy J. Salmon (auth.), Jerome J. Decosse, Paul Sherlock (eds.)

Where do you start to appear for a up to date, authoritative article at the analysis or administration of a selected malignancy? The few common onco­ logy textbooks are mostly outdated. unmarried papers in really good journals are informative yet seldom entire; those are extra usually initial studies on a truly constrained variety of sufferers. sure normal journals fre­ quently submit reliable indepth studies of melanoma issues, and released sympo­ sium lectures are frequently the easiest overviews to be had. regrettably, those stories and supplementations look sporadically, and the reader can by no means confirm while an issue of targeted curiosity might be coated. melanoma therapy and study is a sequence of authoritative volumes which goal to satisfy this want. it truly is an try to identify a serious mass of oncology literature protecting almost all oncology issues, revised often to maintain the assurance brand new, simply to be had on a unmarried library shelf or by way of a unmarried own subscription. we've got approached the matter within the following type. First, through divid­ ing the oncology literature into particular subdivisions similar to lung melanoma, genitourinary melanoma, pediatric oncology, and so on. moment, via asking eminent experts in each one of those components to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor sort is roofed in a quantity showing often and predictably, discussing present prognosis, staging, markers, all kinds of therapy modalities, simple biology, and more.

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The lack of resemblance between the actual doubling times for mice and man may relate to the sizes of tumors involved since doubling time often increases with increasing size and the tumors in mice are relatively small. Xenograft lines of colon carcinoma have been tested in immunosuppressed mice against several single chemotherapeutic agents, each of which altered tumor growth, regardless of the histological appearance of the line [109]. The greatest response was achieved with the use of 5-FU. Studies of cell proliferation have been instrumental in the development and use of cell cycle specific drugs in combination with cell-cycle nonspecific agents.

Chemical sympathectomy significantly lowered the mitotic rate in normal crypts but did not influence it in adenocarcinomas [78]. The use of drugs releasing norepinephrine as well as alphaadrenergic manipulation influenced cell proliferation in the normal crypts while tumor cell proliferation was unaltered. Obseryations such as these indicate autonomic neural control over normal colonic proliferative activity whereas it is reduced or absent in neoplastic tissue. Again selective advantage may perhaps be achieved between tumor and normal colonic mucosa by manipulation of neural response thus altering the ratio of proliferative cells in both tissues [78].

It is thus likely that genetic factors are operating, but the results cannot be considered decisive since cancer patients and their spouses share a similar environment only during their married life. It is possible that carcinogenic factors operating in youth are important in the aetiology of the disease. These investigations do suggest, however, that important exogenous factors for stomach cancer are not present in the home environment of patients with stomach cancer during adult life. 5. The Genetic Basis of Gastric Cancer Intense research during the past decade has resulted in several discoveries which suggest not only that there are a number of genes which play a relatively minor role in susceptibility of gastric cancer, such as the genes for blood group A, but also there may be genes which are able to make a major contribution to cancer susceptibility.

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