By Brian H. Vickery, Bruno Lunenfeld (auth.), B. H. Vickery, B. Lunenfeld (eds.)
These 4 volumes comprising "GnRH Analogues in melanoma and Human copy" are a distillation of the displays of the invited audio system at a landmark foreign Symposium bearing an analogous identify, prepared via one among us (B. L. ) and held in Geneva, Switzerland in February 1988. The Symposium was once really interdisciplinary spanning gonadal hormone established affliction together with numerous types of melanoma and varying to regulate of fertility, either professional- and notion. The foreign taste might be stuck from the 480 contributors and 259 individuals drawn from 14 international locations. The Symposium, and hence this ebook, shouldn't have been attainable with no the backing of The foreign Committee for learn in copy and the sponsorship of the overseas Society of Gynecologic Endocrinology, The Swiss Society of Fertility and Sterility, The collage of Geneva institution of medication, The Swiss Society of Endocrinology and the USA starting place for experiences in copy Inc. , and aid from the area overall healthiness association. B. H. Vickery B. Lunenfeld June 1989 checklist OF members TO THE sequence H. Bartermann A. Abbondante First Institute of Obstetrics and Urologische Universitatsklinik Kiel Gynecology Arnold-Heller Strasse 7 college "La Sapienza" D-2300 Kiel 1, FRG Rome,ltaly M. Bartholomew P. Abel division of Medicine/Endocrinology division of Urology Milton S. Hershey clinical middle Hammersmith health facility Pennsylvania nation collage DuCane street PO field 850, Hershey, PA 17033, united states London W12 OHS, united kingdom D. Beck H.
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Extra info for GnRH Analogues in Cancer and Human Reproduction: Volume IV Precocious Puberty, Contraception and Safety Issues
Endocr Rev, 1, 404 41. Parvinen, M, Nikula, Hand Huhtaniemi, I (1984). Influence of rat seminiferous tubules on Leydig cell testosterone production in vitro. Mol Cell Endocrinol, 37, 331 42. Seguin, C, Belanger A, Labrie, F and Hansel, W (1982). Study of the direct action of luteinizing hormone-releasing hormone agonists at the testicular level in intact rats treated with an antiluteinizing hormone serum. Endocrinology, llQ, 524 43. Sharpe, RM (1983). Local control of testicular function. Quart J Exp Physiol, 68, 265 44.
Styne, OM, Harris DA, Egli, CA, Conte, FA, Kaplan, FA, Kaplan SL, Rivier, J, Vale, WW and Grumbach, MM (1985). Treatment of true precocious puberty with a potent luteinizing hormone-releasing factor agonist: effect on growth, sexual maturation, pelvic sonography and the hypothalamicpituitary-gonadal axis. J Clin Endocrinol Metab, 61, 142 7. Sandow, J and Beier, B (1985). LHRH agonistS-- mechanism of action and effect on target tissues. 121. (New York: Alan Liss) 8. Sandow, J, Rechenberg, Wv, Jerzabek, G and Stoll, W (1978).
17 Treatment of adult rats for 3 to 6 months with daily buserelin injections has no lasting effect on fertility. However, after treatment for 12 or 24 months, irreversible damage to spermatogenesis frequently occurs, associated with proliferation and hyperplasia of the Leydig cells. The steroidogenic lesions are less severe when the same dose is given in two injections per week, and they are absent during release of buserelin from implants. The species-specific changes in steroid metabolism during buserelin treatment in rats differ from those observed in man.