Download Handbook of metastatic breast cancer by Charles Swanton, Stephen R. D. Johnston PDF

By Charles Swanton, Stephen R. D. Johnston

Recent advancements with novel systemic medicinal drugs, palliative surgical options and diagnostic imaging have given wish for the remedy of sufferers whose breast melanoma has unfold past its basic tumour. Written by way of a workforce from best melanoma facilities in Europe, together with the UK's Royal Marsden clinic, the Handbook of Metastatic Breast melanoma, moment Edition offers complicated medical details and suggestions on scientific difficulties linked to metastatic breast cancer.

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Handbook of metastatic breast cancer

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Proc Am Soc Clin Oncol 2004; 23: Abstract 515. 27. Geisler J, Haynes B, Anker G, Dowsett M, Lonning PE. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. J Clin Oncol 2002; 20: 751–7. 28. Rose C, Vtoraya O, Pluzanska A, et al. An open randomised trial of second-line endocrine therapy in advanced breast cancer: comparison of the aromatase inhibitors letrozole and anastrozole.

20 HANDBOOK OF METASTATIC BREAST CANCER letrozole had a significantly higher objective tumour response rate (30% vs. 001), clinical benefit rate (49% vs. 4 months vs. 0001). Of particular note in this trial, nearly 20% patients had received tamoxifen prior in the adjuvant setting, although had ceased more than a year (median 3 years) prior to the development of metastatic disease; in this subgroup, re-treatment with tamoxifen had a low response rate of 8% compared with a 32% response rate with letrozole.

Evaluation of fulvestrant in women with advanced breast cancer and progression on prior aromatase inhibitor therapy: a phase II trial of the North Central Cancer Treatment Group. Breast Cancer Res Treat 2004; 88(Suppl 1): S38 Abstract 409. 51. Petruzelka L, Zimovjanova M. Fulvestrant in postmenopausal women with metastatic breast cancer progressing on prior endocrine therapy – results from an expanded access programme. Eur J Cancer 2004; (Suppl 2): 132 Abstract 264. com by Yale University on 11/24/11 For personal use only.

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